Motif ID: FOX{C1,C2}.p2

Z-value: 0.934


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOXC1chr6_+_1610680-0.554.1e-03Click!
FOXC2chr16_+_86600856-0.311.3e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_150187028 3.238 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr2_+_127413739 2.924 GYPC
glycophorin C (Gerbich blood group)
chr8_+_54793516 2.824 RGS20
regulator of G-protein signaling 20
chr2_+_102979096 2.461 NM_003855
IL18R1
interleukin 18 receptor 1
chr1_-_120612019 1.962 NOTCH2
notch 2
chr16_+_57050985 1.818 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr5_+_35856990 1.806 NM_002185
IL7R
interleukin 7 receptor
chr11_-_8832881 1.794 NM_139157
ST5
suppression of tumorigenicity 5
chrX_-_63450486 1.742 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr18_+_61554938 1.737 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr15_-_58306185 1.708 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr7_-_107880492 1.659 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr1_-_150738255 1.583 CTSS
cathepsin S
chr7_-_92747269 1.494 SAMD9
sterile alpha motif domain containing 9
chr7_-_92747317 1.362 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr22_+_20909221 1.305 MED15
mediator complex subunit 15
chr7_-_108096693 1.291 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr16_+_56598960 1.289 NM_032935
MT4
metallothionein 4
chr20_-_62199106 1.274 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr5_-_58882274 1.173 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_9225780 1.088 DENND5A
DENN/MADD domain containing 5A
chr10_+_96522457 1.027 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr5_-_169816637 0.938 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr12_-_56236614 0.905 NM_002429
MMP19
matrix metallopeptidase 19
chr5_+_54320083 0.883 NM_002104
GZMK
granzyme K (granzyme 3; tryptase II)
chr8_+_54793409 0.881 NM_003702
RGS20
regulator of G-protein signaling 20
chr10_+_90424145 0.877 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr17_-_79623561 0.869 NM_002602
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr2_-_233641225 0.864 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr13_-_43566301 0.859 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr17_-_16875388 0.835 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr19_+_48828820 0.812 EMP3
epithelial membrane protein 3
chr14_-_91710851 0.805 NM_001177676
GPR68
G protein-coupled receptor 68
chr14_+_29236882 0.797 FOXG1
forkhead box G1
chr1_-_47080793 0.789 NM_145279
MOB3C
MOB kinase activator 3C
chr4_+_169013687 0.787 NM_007193
ANXA10
annexin A10
chr4_-_122148620 0.779 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr9_+_116918230 0.775 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr17_-_64225496 0.758 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_+_28475233 0.753 NM_004904
CREB5
cAMP responsive element binding protein 5
chr12_+_15125955 0.751 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr13_+_97874704 0.750 MBNL2
muscleblind-like 2 (Drosophila)
chr5_+_140797243 0.739 NM_018927
PCDHGB7
protocadherin gamma subfamily B, 7
chr6_+_158438079 0.720 NM_001178088
SYNJ2
synaptojanin 2
chr5_-_160279045 0.706 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_+_140710203 0.700 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chrX_-_130423199 0.692 IGSF1
immunoglobulin superfamily, member 1
chr3_+_132036276 0.691 ACPP
acid phosphatase, prostate
chr11_+_61957687 0.681 NM_006552
SCGB1D1
secretoglobin, family 1D, member 1
chr12_-_46633551 0.673 SLC38A1
solute carrier family 38, member 1
chr3_-_71353910 0.666 NM_001244812
FOXP1
forkhead box P1
chr6_+_12717036 0.661 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr10_+_111765725 0.645 NM_019903
ADD3
adducin 3 (gamma)
chr6_+_44095357 0.634 NM_018426
TMEM63B
transmembrane protein 63B
chr1_-_36948423 0.634 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr19_+_7030593 0.633 NM_001136507
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr16_+_29831714 0.630 NM_005115
NM_017458
MVP

major vault protein

chr3_-_191048324 0.621 NM_198152
UTS2D
urotensin 2 domain containing
chr16_+_29831755 0.619 MVP
major vault protein
chr5_-_59783885 0.618 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_+_7745284 0.613 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr20_+_9198036 0.609 NM_182797
PLCB4
phospholipase C, beta 4
chr6_-_29055048 0.609 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr2_+_69201704 0.576 NM_019617
GKN1
gastrokine 1
chr10_+_82214066 0.575 TSPAN14
tetraspanin 14
chr8_+_55528626 0.569 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr4_+_71263598 0.568 NM_021225
PROL1
proline rich, lacrimal 1
chr10_+_82214071 0.559 TSPAN14
tetraspanin 14
chr9_-_15250113 0.559 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr1_+_16767166 0.559 NM_001145277
NM_001145278
NM_018090
NECAP2


NECAP endocytosis associated 2


chr1_+_16767218 0.558 NECAP2
NECAP endocytosis associated 2
chr13_-_26625164 0.542 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr7_+_91924291 0.516


chr19_+_38810461 0.513 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr10_+_82214074 0.511 TSPAN14
tetraspanin 14
chr3_-_119278402 0.508 NM_005191
CD80
CD80 molecule
chr5_+_173472692 0.504 NM_015980
HMP19
HMP19 protein
chr19_+_15197790 0.503 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr4_-_38858407 0.485 NM_006068
TLR6
toll-like receptor 6
chr17_-_39093671 0.479 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr14_+_51026853 0.466 ATL1
atlastin GTPase 1
chr1_-_202129731 0.462 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr2_+_127413678 0.460 NM_002101
NM_016815
GYPC

glycophorin C (Gerbich blood group)

chrX_+_41548225 0.459 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr22_+_18043147 0.458 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr12_-_57030083 0.456 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr10_+_82213892 0.453 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr12_-_102872329 0.452 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_+_100867739 0.443 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr13_-_53313835 0.441 LECT1
leukocyte cell derived chemotaxin 1
chr13_+_50070096 0.432 PHF11
PHD finger protein 11
chr7_-_55930444 0.426 NM_207366
SEPT14
septin 14
chr4_+_71494460 0.422 NM_031889
ENAM
enamelin
chr15_+_34261088 0.421 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr11_-_114430579 0.420 NM_152315
FAM55A
family with sequence similarity 55, member A
chr20_-_44175995 0.418 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr11_+_120973374 0.417 NM_005422
TECTA
tectorin alpha
chr20_+_9494995 0.412 NM_001199897
NM_012261
LAMP5

lysosomal-associated membrane protein family, member 5

chr2_+_191002485 0.406 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr14_+_51026742 0.405 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr11_-_10830581 0.402 NM_001042559
NM_001418
EIF4G2

eukaryotic translation initiation factor 4 gamma, 2

chr17_-_67311773 0.389 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr1_+_244515936 0.384 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr15_+_57884101 0.384 NM_001018100
NM_152451
NM_001018090
NM_001018091
MYZAP

GCOM1

myocardial zonula adherens protein

GRINL1A complex locus 1

chr17_+_8214139 0.384 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chrX_-_40506800 0.383 NM_144970
CXorf38
chromosome X open reading frame 38
chr8_+_20054899 0.381 ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr20_+_45523505 0.380 EYA2
eyes absent homolog 2 (Drosophila)
chr2_-_202563353 0.379 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_-_85430117 0.373 NM_206929
SYTL2
synaptotagmin-like 2
chr8_-_27115935 0.371 STMN4
stathmin-like 4
chr5_+_304290 0.370 NM_001242412
NM_020731
AHRR

aryl-hydrocarbon receptor repressor

chrX_-_40506666 0.363 CXorf38
chromosome X open reading frame 38
chr17_+_3118911 0.361 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr8_-_27115897 0.360 NM_030795
STMN4
stathmin-like 4
chr2_-_49381555 0.358 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr5_-_87969135 0.357 LINC00461
long intergenic non-protein coding RNA 461
chr5_+_140734767 0.355 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr1_-_206945725 0.352 NM_000572
IL10
interleukin 10
chr21_-_27423423 0.346


chr2_+_158958381 0.345 NM_173355
UPP2
uridine phosphorylase 2
chr22_+_50925212 0.344 NM_017584
MIOX
myo-inositol oxygenase
chr11_-_10830452 0.343 EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr4_+_39063851 0.339 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr5_+_173472737 0.336 HMP19
HMP19 protein
chr11_-_16497917 0.333 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr4_-_48136245 0.331 NM_003328
TXK
TXK tyrosine kinase
chr3_+_64670779 0.331 ADAMTS9-AS2
ADAMTS9 antisense RNA 2 (non-protein coding)
chr13_+_52436116 0.329 NM_031290
CCDC70
coiled-coil domain containing 70
chr2_-_25141855 0.320 NM_004036
ADCY3
adenylate cyclase 3
chr10_+_43633880 0.320 NM_018590
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr4_-_153273683 0.319 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr4_-_122854192 0.318 NM_003305
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr19_+_42817434 0.317 NM_173633
TMEM145
transmembrane protein 145
chr19_+_17666502 0.317 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr10_-_99790346 0.317 CRTAC1
cartilage acidic protein 1
chr6_+_123100860 0.316 FABP7
fatty acid binding protein 7, brain
chr12_+_100867550 0.316 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr19_-_36054559 0.314 NM_000704
ATP4A
ATPase, H+/K+ exchanging, alpha polypeptide
chr20_+_17680592 0.313 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr9_+_71650643 0.312 FXN
frataxin
chr5_+_38845962 0.308 NM_003999
OSMR
oncostatin M receptor
chr22_+_39916563 0.306 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr2_-_74570533 0.306 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr1_+_196857143 0.304 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr1_-_24239758 0.297 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr1_+_180882312 0.294 NM_020950
KIAA1614
KIAA1614
chr6_+_4890225 0.289 NM_001143971
CDYL
chromodomain protein, Y-like
chr20_-_1373744 0.285 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr17_-_1090562 0.285 NM_001159746
ABR
active BCR-related gene
chr11_-_13517525 0.283 NM_000315
PTH
parathyroid hormone
chr3_-_164914448 0.281 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr20_+_45523523 0.279 EYA2
eyes absent homolog 2 (Drosophila)
chr5_+_140797210 0.278 NM_032101
PCDHGB7
protocadherin gamma subfamily B, 7
chr22_+_51176623 0.277 NM_001097
ACR
acrosin
chr2_+_27255837 0.276 TMEM214
transmembrane protein 214
chr13_-_99959649 0.276 NM_004951
GPR183
G protein-coupled receptor 183
chr5_+_140797270 0.275 PCDHGB7
protocadherin gamma subfamily B, 7
chr12_-_117799410 0.274 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr6_-_10419786 0.273 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_+_11039419 0.273 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr11_-_2950593 0.272 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr17_-_41836132 0.269 NM_025237
SOST
sclerostin
chr19_+_38810540 0.268 KCNK6
potassium channel, subfamily K, member 6
chr2_+_161993465 0.266 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr3_-_116164363 0.264 NM_002338
LSAMP
limbic system-associated membrane protein
chr8_+_104831415 0.264 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr1_+_16767235 0.263 NECAP2
NECAP endocytosis associated 2
chr1_+_171481164 0.262 PRRC2C
proline-rich coiled-coil 2C
chr1_+_8384389 0.261 NM_001080397
SLC45A1
solute carrier family 45, member 1
chr1_+_160085519 0.260 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_-_162381805 0.257 NM_053282
SH2D1B
SH2 domain containing 1B
chr22_-_40859423 0.254 MKL1
megakaryoblastic leukemia (translocation) 1
chr5_-_35230822 0.252 NM_000949
PRLR
prolactin receptor
chr1_-_54199876 0.249 NM_147193
GLIS1
GLIS family zinc finger 1
chr10_-_27057776 0.246 ABI1
abl-interactor 1
chr11_+_1860718 0.245 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr12_+_54378929 0.242 NM_017409
HOXC10
homeobox C10
chr18_+_32335939 0.241 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr4_-_46125929 0.240 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr10_+_7745354 0.240 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_117800067 0.239 NM_001077263
NM_001206789
NM_001206790
NM_001244995
TMPRSS13



transmembrane protease, serine 13



chr21_-_36421630 0.237 RUNX1
runt-related transcription factor 1
chrX_+_115301957 0.237 NM_000686
AGTR2
angiotensin II receptor, type 2
chr10_+_7745341 0.236 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr16_-_31160828 0.231 PRSS36
protease, serine, 36
chr12_-_56694082 0.227 CS
citrate synthase
chr16_-_53737713 0.223 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr19_-_33462791 0.223 NM_032816
CEP89
centrosomal protein 89kDa
chr3_-_121379757 0.220 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_+_111772332 0.218 NM_001025199
CHI3L2
chitinase 3-like 2
chr19_-_50432731 0.218 NUP62
nucleoporin 62kDa
chr2_-_161056762 0.216 ITGB6
integrin, beta 6
chr14_+_88471467 0.214 NM_003608
GPR65
G protein-coupled receptor 65
chr4_+_15376174 0.208 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chrX_-_130423387 0.206 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr6_-_41122025 0.204 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr17_+_7623038 0.203 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr1_+_111413820 0.202 NM_001040033
CD53
CD53 molecule
chr11_+_55594694 0.202 NM_001004739
OR5L2
olfactory receptor, family 5, subfamily L, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.49 5.23e-03 GO:0007186 G-protein coupled receptor protein signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 7.24e-06 GO:0071944 cell periphery
1.47 9.20e-05 GO:0005886 plasma membrane
1.80 6.08e-03 GO:0031226 intrinsic to plasma membrane
1.57 6.69e-03 GO:0044459 plasma membrane part
1.80 7.34e-03 GO:0005887 integral to plasma membrane
1.58 1.18e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.73 2.20e-03 GO:0004872 receptor activity
1.62 4.46e-03 GO:0004871 signal transducer activity
1.62 4.46e-03 GO:0060089 molecular transducer activity
1.83 4.86e-03 GO:0004888 transmembrane receptor activity
5.72 2.45e-02 GO:0004896 cytokine receptor activity